Publications by authors named "C PORRO"
Neurodegenerative diseases are characterized by progressive loss of neurons and persistent inflammation. Neurons are terminally differentiated cells, and lost neurons cannot be replaced since neurogenesis is restricted to only two neurogenic niches in the adult brain, whose neurogenic potential decreases with age. In this regard, the astrocytes reprogramming into neurons may represent a promising strategy for restoring the lost neurons and rebuilding neural circuits.
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- Neuroinflammation involves immune responses, especially by microglia, which can activate in two ways: M1 (pro-inflammatory) and M2 (anti-inflammatory).
- Irisin, a muscle-released peptide, affects microglial cells and may offer neuroprotective benefits by influencing the NLRP3 inflammasome after exposure to pro-inflammatory stimuli.
- The study suggests that irisin promotes anti-inflammatory M2 characteristics in microglia and may be a promising strategy for preventing neurodegenerative diseases.
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- Researchers examined lentil seed coats for their health benefits, particularly in managing inflammatory bowel diseases (IBDs).
- They used both traditional and microwave-assisted extraction methods to obtain extracts, finding the microwave method with ethyl acetate the most effective for anti-inflammatory and spasmolytic activity.
- The study concluded that this extract could support intestinal health, indicating its potential as a dietary supplement to help treat intestinal issues.
Hierarchical models have been proposed to explain how the brain encodes actions, whereby different areas represent different features, such as gesture kinematics, target object, action goal, and meaning. The visual processing of action-related information is distributed over a well-known network of brain regions spanning separate anatomical areas, attuned to specific stimulus properties, and referred to as action observation network (AON). To determine the brain organization of these features, we measured representational geometries during the observation of a large set of transitive and intransitive gestures in two independent functional magnetic resonance imaging experiments.
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- The study analyzed the management and outcomes of Hepatitis C virus (HCV) in children at a Milan hospital over a 25-year period, noting a focus on new treatments and liver stiffness measurements.
- Out of 57 pediatric patients, 14% cleared the virus on their own, while 58% received treatment with successful outcomes, indicated by undetectable HCV RNA levels post-therapy.
- The research highlights that while many children show normal liver stiffness measurements before age 12, those with abnormal results experienced significant improvement after treatment with direct-acting antiviral agents, emphasizing the need for further studies on liver elastography in this population.