Publications by authors named "C P Skipper"
Cryptococcal meningitis is a fungal infection that is typically caused by and most commonly seen in severely immunosuppressed patient. This disease causes severe neurologic disease due to elevated intracranial pressures. In this case report, we describe a patient with newly diagnosed HIV presenting to the hospital with cryptococcal meningitis complicated by sudden vision loss.
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- Multisystem inflammatory syndrome in children (MIS-C) is a serious condition linked to COVID-19, causing inflammation and affecting multiple organs.
- Research indicates that while antibodies are produced, there are issues with cell-mediated immune responses, particularly with natural killer (NK) cells, which show reduced functionality.
- Possible treatments, like using CD16 cellular engagers, may improve NK cell function and help address the immune system's dysregulation associated with MIS-C.
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- Individuals with HIV and cryptococcal antigenemia face a high risk of developing cryptococcal meningitis or death, with factors like baseline CrAg titer and CRP levels being crucial for assessing outcomes.* -
- In a study of 182 participants, those with elevated CRP levels had a higher rate of meningitis or death compared to those with normal CRP levels, specifically revealing that elevated CRP impacted low CrAg titer individuals more significantly.* -
- The research indicates a complex relationship between CrAg titers and CRP levels, suggesting that future studies should further explore this interaction to improve patient risk assessments and outcomes.*
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- Cryptococcal meningitis poses a significant risk for individuals with AIDS, and the study aims to evaluate if adding a high-dose of liposomal amphotericin B to fluconazole can reduce the incidence of meningitis among asymptomatic CrAg-positive individuals.
- In a trial with participants from Uganda, those with low plasma CrAg titers were given either liposomal amphotericin B with fluconazole or fluconazole alone for 24 weeks to assess meningitis-free survival.
- Results showed no significant difference in meningitis or death rates between the two groups, suggesting that for asymptomatic patients with low CrAg levels, adding liposomal amphotericin B does not improve outcomes and may lead to
Background: Limited data exist on the antifungal activity of daily liposomal amphotericin B with flucytosine induction regimens for cryptococcal meningitis, which are recommended in high-income countries. Liposomal amphotericin B monotherapy at 3 mg/kg previously failed to meet non-inferiority criteria compared to amphotericin B deoxycholate in its registrational clinical trial. We aimed to compare the quantitative antifungal activity and mortality between daily amphotericin B deoxycholate and daily liposomal amphotericin among persons with HIV-related cryptococcal meningitis receiving adjunctive flucytosine 100 mg/kg/day.
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