Lu-Labeled Heterodimeric Agent with High Stability Targeting Neovascularization for Tumor Radioligand Therapy.

Radiopharmaceutical theranostics holds significant promise in tumor diagnosis and treatment, but suboptimal tumor uptake and retention remain a persistent limitation. We have conjugated a unique albumin binder to our previously developed heterodimeric precursor HX01 and achieved a novel precursor L6, aiming to prolong circulation time and enhance tumor accumulation and retention. However, we observed that the NGR sequence of L6 was gradually rearranged to iso-DGR under alkaline conditions, resulting in decreased stability.

Maximizing Output Energy via Suppressing Charge Loss and Increasing Load Voltage in Charge Extraction Process.

The effective collection of interfacial tribo-charges and an increase in load voltage are two essential factors that improve the output energy of triboelectric nanogenerators. However, some tribo-charges are hardly collected through one or multiple integrated side electrodes based on corona discharge, and their load voltages are limited by air breakdown in adjacent electrodes. In this study, a dynamic quasi-dipole potential distribution model is proposed to systematically reveal the mechanisms of interfacial tribo-charge loss.

An evolutionary dynamics analysis of the plant DEK gene family reveals the role of BnaA02g08940D in drought tolerance.

DEK is a chromatin protein that interacts with DNA to influence chromatin formation, thereby affecting plant growth, development, and stress response. This study investigates the molecular evolution of the DEK family in plants, with a particular focus on the Brassica species. A total of 127 DEK genes were identified in 34 plants and classified into seven groups based on the phylogenetic analysis.

Jasmonic acid improves cadmium tolerance in rice (Oryza sativa) by reducing the production of nitric oxide.

The involvement of jasmonic acid (JA) in the rice's response to cadmium (Cd) stress is well recognized, though the underlying mechanisms remain unclear. In this study, exposure to Cd stress rapidly elevated endogenous JA concentrations in rice roots, meanwhile, a mutant coleoptile photomorphogenesis 2 (cpm2) which produces less JA, was more sensitive to Cd stress than its wild type (WT). JA mitigated Cd toxicity by decreasing Cd absorption in root cell wall and shoot, which was achieved by up-regulating the expression of the Cd-chelation and efflux-related genes such as OsHMA3, OsABCG36 and OsCAL1; down-regulating the transcript level of the Cd uptake and translocation-related genes, including OsHMA2, OsCCX2, OsNRAMP1/5, and OsZIP5/7.

Efficacy and safety of KN026 and docetaxel for HER2-positive breast cancer: a phase II clinical trial.

Background: The standard first-line treatment for human epidermal growth factor receptor 2 (HER2)-positive recurrent/metastatic breast cancer currently includes pertuzumab plus trastuzumab and docetaxel. This study aimed to evaluate the effectiveness of KN026, an anti-HER2 bispecific antibody, plus docetaxel in first-line treatment of HER2-positive recurrent/metastatic breast cancer.

Methods: This open-label, single-arm, phase II study enrolled patients with HER2-positive recurrent/metastatic breast cancer in 19 centers across China from December 30, 2019 to May 27, 2021.