Publications by authors named "C P Rooney"
Unlabelled: Target product profiles (TPPs) specify the essential properties tests must have to be able to address an unmet clinical need. To explore how early economic modeling can help to define TPP specifications based on cost-effectiveness considerations using the example of a new rapid diagnostic for infection (CDI), a contagious health care-associated infection causing potentially fatal diarrhea. A resource-constrained simulation model was developed to compare a hypothetical test for CDI with current practice (i.
View Article and Find Full Text PDFBackground: Social isolation and loneliness have both been associated with psychological health and cognitive decline in older adults. This study investigated the impact of social interaction through remote communication technologies during the COVID-19 pandemic on the cognitive and psychological status of older adults with and without cognitive impairment.
Methods: Participants were recruited from Boston (USA) and Chieti (Italy).
Article Synopsis
- The study aimed to clarify inconsistent findings regarding the gut bacteria Prevotellaceae and its role in rheumatoid arthritis (RA) by comparing gut microbiome changes in individuals who progressed to RA against those who did not.
- Researchers tracked participants at risk of RA over 15 months, discovering significant differences in Prevotellaceae levels and overall gut microbiome instability in those who progressed to RA, occurring approximately 10 months before RA symptoms appeared.
- The findings suggest that changes in the gut microbiome, particularly involving Prevotellaceae, may be linked to RA development, but it remains uncertain whether these changes initiate the disease or are a result of it.
Background: We investigate the association of postoperative radiotherapy (PORT) volumes and salivary function in oral cavity SCC (OSCC).
Methods: OSCC patients undergoing PORT 2005-2021 underwent modified Schirmer test (MST) pre-PORT, 6 and/or 12 months post-PORT. Hyposalivation rates were compared by PORT volumes.
Article Synopsis
- Epstein-Barr virus (EBV) is linked to various types of lymphomas, and while EBV-specific T-cell (EBVST) therapies have shown effectiveness, not all patients benefit from them.
- A study analyzing immune responses in 56 lymphoma patients receiving EBVST treatments discovered distinct antibody profiles that differentiate responders from non-responders, particularly at 3 months after treatment.
- The research identified 10 specific IgG antibodies that can predict clinical responses, suggesting that these EBV-directed antibodies may serve as biomarkers for patient outcomes in EBV-associated lymphoma treatments.