Publications by authors named "C P Rajadurai"
Background: Immunotherapy is the cornerstone of treatment for many cancers. The effectiveness of immunotherapy in hospitalized patients is unknown due to the exclusion of this fragile population from clinical trials. This study evaluates the efficacy of immunotherapy in fragile hospitalized patients.
View Article and Find Full Text PDFColorectal carcinosarcoma is an exceedingly rare subtype of colorectal cancer that displays the histological and molecular features of both mesenchymal and epithelial tumors. Due to its rarity, there are no guidelines regarding the systemic treatment of this disease. This report describes a case of a 76-year-old woman with colorectal carcinosarcoma with extensive metastatic burden treated with carboplatin and paclitaxel.
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- Researchers identified specific microRNAs (miRNAs) in sugarcane that play roles during both compatible and incompatible interactions with the red rot pathogen Colletotrichum falcatum.
- The study utilized next-generation sequencing to analyze 80 miRNA families, which included 980 miRNAs, and revealed their target genes related to various functions such as stress response and signaling pathways.
- The findings show how these miRNAs regulate gene expression in response to the pathogen, advancing our understanding of the molecular mechanisms underpinning sugarcane’s defense against red rot for the first time.
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- Scientists created special gels from substances like alginate, gelatin, and Matrigel that help grow cancer cells in 3D models, which can be used to test how these cells react to drugs.
- They can break down and rebuild these gel models multiple times, allowing them to keep studying the cancer cells for a long time without hurting them.
- This method even helps understand how different cancer types behave and respond to treatments, making it an important tool for cancer research.
The Met/hepatocyte growth factor (HGF) receptor tyrosine kinase (RTK) is deregulated in many cancers and is a recognized target for cancer therapies. Following HGF stimulation, the signaling output of Met is tightly controlled by receptor internalization and sorting for degradation or recycling. Here, we uncover a role for autophagy in selective degradation of Met and regulation of Met-dependent cell migration and invasion.
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