Publications by authors named "C P Osborne"
Grasses are exceptionally productive, yet their hydraulic adaptation is paradoxical. Among C grasses, a high photosynthetic rate (A) may depend on higher vein density (D) and hydraulic conductance (K). However, the higher D of C grasses suggests a hydraulic surplus, given their reduced need for high K resulting from lower stomatal conductance (g).
View Article and Find Full Text PDFCombination chemotherapy remains essential for clinical management of triple-negative breast cancer (TNBC). Consequently, responses to individual agents cannot be easily delineated at the single patient level, even though some patients might not require all drugs in the combination. Herein, we conduct multi-omic analyses of orthotopic TNBC patient-derived xenografts (PDXs) treated with single agent carboplatin, docetaxel, or the combination.
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- Non-melanoma skin cancers (NMSCs) are the most common type of cancer in the U.S., and image-guided superficial radiation therapy (IGSRT) effectively treats them, but the influence of patient comorbidities and socioeconomic status (SES) on treatment outcomes has been under-researched.
- A large retrospective study analyzed nearly 20,000 NMSC lesions to determine how SES and comorbidity levels (using ADI and CCI metrics) affected recurrence rates after IGSRT, finding minimal differences in outcomes for both factors at 2, 4, and 6 years.
- Results showed that neither SES nor comorbidity burden significantly impacted recurrence rates, suggesting that I
Article Synopsis
- Viral lower respiratory tract infection (vLRTI) significantly impacts global child health, prompting research into the host immune responses using proteomics for better understanding and diagnosis.
- The study analyzed 1,305 proteins from tracheal aspirate and plasma of 62 critically ill children, finding 200 differentially expressed proteins that reveal key immune responses, with a robust nine-protein TA classifier showing high diagnostic accuracy (AUC of 0.96).
- It also highlighted the limited correlation between tracheal aspirate and plasma proteins and examined how viral load and bacterial co-infections influence immune signaling pathways.
Introduction: Image guided superficial radiation therapy (IGSRT) is a novel technology which combines traditional superficial radiation therapy (SRT) with high resolution dermal ultrasound (HRDUS) to treat non-melanoma skin cancers (NMSC). Since development, IGSRT use has expanded dramatically in outpatient clinics. We review the IGSRT literature and state-of-the-art operating principles in US dermatologic practices.
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