Publications by authors named "C P Locher"
Studies with negative results are less likely to be published than others, potentially leading to publication bias. Introduced in 2000, trial registration could have participated in decreasing the proportion of unpublished studies. We assessed the proportion of negative randomized controlled trials (RCT) over the last 20 years.
View Article and Find Full Text PDFAim Of The Study: The management of synchronous metastatic rectal cancer (SMRC) is complex and multimodal, involving chemotherapy, surgery and/or radiotherapy. The aim of this study was firstly to confirm the efficacy of the induction FOLFIRINOX, and secondly to evaluate the different therapeutic strategies and outcomes of patients.
Patients And Methods: This French study combined data from a prospective FFCD trial and a multicenter cohort.
Article Synopsis
- Chronic primary musculoskeletal pain (CPMP) significantly impacts public health, with many clinical trials focusing on pharmacological treatments that may not reflect actual clinical situations.
- This study compared a clinical sample of 103 CPMP patients from healthcare records to a larger randomized controlled trial (RCT) sample of 8,665 participants, analyzing demographic data and medications used.
- Findings revealed significant differences in medication distribution between the two groups, highlighting a gap between research and real-world treatment, emphasizing the need for further studies addressing the role of psychiatric comorbidities in CPMP management.
This study critically investigates the aluminium chloride-based colorimetric determination of the total flavonoid content (TFC) of honey. Following a comprehensive review of the recent literature reporting the use of the assay in the determination of TFC in honey, 10 honeys of different botanical origins were investigated using the colorimetric method alongside an artificial honey that was used as a control. Using spiking experiments, this study demonstrates that the flavonoid concentrations commonly found in honey are too low for a direct measurement and thus some of the TFC data reported in the literature might more likely be a reflection of the honey's inherent colour rather than a product of the coordination complex formed specifically between flavonoids and Al ions.
View Article and Find Full Text PDFBackground: Ampullary carcinoma (AC) is a rare and severe gastrointestinal cancer with a disease recurrence rate of around 40% after curative-intent surgery and for which the main prognostic factors and adjuvant treatment decision remain a matter of debate.
Patients And Methods: The FFCD-AC cohort is a French nationwide prospective cohort, which included patients with non-metastatic resected AC. The primary objective of this study was to describe prognostic factors associated with disease-free survival (DFS) and overall survival (OS) after pancreaticoduodenectomy (PD) so as to propose a user-friendly score to better estimate the risk of recurrence.