Immunofluorescence analyses of respiratory epithelial cells aid the diagnosis of nephronophthisis.

Background: Nephronophthisis (NPH) comprises a heterogeneous group of inherited renal ciliopathies clinically characterized by progressive kidney failure. So far, definite diagnosis is based on molecular testing only. Here, we studied the feasibility of NPHP1 and NPHP4 immunostaining of nasal epithelial cells to secure and accelerate the diagnosis of NPH.

Design of Polymer Carriers for Optimized Pheromone Release in Sustainable Insect Control Strategies.

Semiochemicals such as pheromones play a major role in communication between insects, influencing their spatial orientation, aggregation, defense, and mating. The rational chemical design of precision pheromone-releasing materials are increased the efficiency of pheromone-based plant protection agents. Decades of research is begun to unravel the complex communication structures regulated by semiochemicals, from the neuronal perception of specific chemical substances to the behavioral responses in hundreds of species, including many devastating pest insects.

Numerical analysis of micro-optics based single photon sources via a combined physical optics and rigorous simulations approach.

The use of 3D printed micro-optical components has enabled the miniaturization of various optical systems, including those based on single photon sources. However, in order to enhance their usability and performance, it is crucial to gain insights into the physical effects influencing these systems via computational approaches. As there is no universal numerical method which can be efficiently applied in all cases, combining different techniques becomes essential to reduce modeling and simulation effort.

Freeform surface for light shaping by iterative design via Fourier domain.

We extend our previous work [Yang et al., Opt. Express29, 3621 (2021)10.