Publications by authors named "C P H Lexis"
A randomized embedded multifactorial adaptive platform for extra corporeal membrane oxygenation (REMAP ECMO) - design and rationale of the left ventricular unloading trial domain.
Am Heart J
January 2025
Article Synopsis
- ECMO (Extracorporeal Membrane Oxygenation) has high complication rates, prompting the need for improved management strategies, which led to the development of the REMAP ECMO platform to investigate effective patient management techniques.* -
- The REMAP ECMO platform allows for multiple adaptive randomized controlled trials, with the first focusing on the effects of early left ventricular unloading via intra-aortic balloon pumping compared to ECMO alone for cardiogenic shock patients in the ICU.* -
- The primary outcome aims to determine successful weaning from ECMO at 30 days, while secondary outcomes include intervention needs, survival rates, and quality of life, all analyzed using a flexible Bayesian statistical framework.*
Article Synopsis
- Researchers improved a model called Deep Embedded Clustering (DEC) to better handle different types of data, like numbers and categories.
- They created a new version called X-DEC by using a special tool (an X-shaped variational autoencoder) to make it work better.
- After testing both models on patients in intensive care, they found that while both created clear groups, X-DEC gave more consistent results.
Background: Individuals with type 2 diabetes mellitus (T2DM) have an increased risk for developing macrovascular disease (MVD) manifested by atherosclerosis. Phenotypically and functionally different monocyte subsets (classical; CD14CD16, non-classical; CD14CD16, and intermediate; CD14CD16) including pro-angiogenic monocytes expressing Tie2 (TEMs) can be identified. Here we investigated monocyte heterogeneity and its association with T2DM and MVD.
View Article and Find Full Text PDF• Fibrous strand rupture is a rare but possible cause of (acute) aortic regurgitation. • Transesophageal echocardiography could clarify the mechanism of aortic regurgitation. • Emergency cardiac surgery could be a salvage therapy in severe aortic regurgitation.
View Article and Find Full Text PDFObjectives: Preclinical and clinical studies suggested cardioprotective effects of metformin treatment. In the GIPS-III trial, 4 months of metformin treatment did not improve left ventricular ejection fraction in patients presenting with ST-elevation myocardial infarction (STEMI). Here, we report the 2-year follow-up results.
View Article and Find Full Text PDF