Insights into Landscape Structure Change in Urbanising Rainforest and Guinea Savanna Ecological Regions of Nigeria.

In the face of unabated urban expansion, understanding the intrinsic characteristics of landscape structure is pertinent to preserving ecological diversity and managing the supply of ecosystem services. This study integrates machine-learning-based geospatial and landscape ecological techniques to assess the dynamics of landscape structure in cities of the rainforest (Akure and Owerri) and Guinea savanna (Makurdi and Minna) ecological regions of Nigeria between 1986 and 2022. Supervised classification using the random forest (RF) machine-learning classifier was performed on Landsat images on the Google Earth Engine (GEE) platform, and landscape metrics were calculated with FRAGSTATS to assess landscape composition, configuration, and connectivity.

Inhibition of prefrontal glutamatergic neuron activity during the recovery period following chronic stress disrupts fear memory in male rats: potential role of the infralimbic cortex.

Chronic stress typically leads to deficits in fear extinction. However, when a delay occurs from the end of chronic stress and the start of fear conditioning (a "recovery"), rats show improved context-cue discrimination, compared to recently stressed rats or nonstressed rats. The infralimbic cortex (IL) is important for fear extinction and undergoes neuronal remodeling after chronic stress ends, which could drive improved context-cue discrimination.

Expanding the Toolbox: A Palliative Care Lecture Series for Oncology Advanced Practice Providers.

Purpose: Initiation of early palliative care (PC) is vital in order to assure that the physical, psychological, spiritual, and social needs of patients and their families are addressed before, during, and after treatment for a serious illness. According to the World Health Organization, PC is patient-and family-centered care that optimizes quality of life by anticipating, preventing, and treating suffering. It is holistic care that addresses the physical, psychosocial, and spiritual needs of patients and their families.

Immune modules to guide diagnosis and personalized treatment of inflammatory skin diseases.

Previous advances have identified immune pathways associated with inflammatory skin diseases, leading to the development of targeted therapies. However, there is a lack of molecular approaches that delineate these pathways at the individual patient level for personalized diagnostic and therapeutic guidance. Here, we conduct a cross-comparison of expression profiles from multiple inflammatory skin diseases to identify gene modules defining relevant immune pathways.