Correlating symptom severity index, clinical diagnostic criteria of CTS-6 and timed Phalen's test in clinical evaluation of carpal tunnel syndrome.

Background: Carpal Tunnel Syndrome (CTS) poses significant diagnostic challenges, especially in resource-limited settings. Reliable tools such as the 6-item Symptom Severity Index, Timed Phalen's Test (TPT) and CTS-6 are promising but under investigated. Correlation between these tools and symptom severity remains underexplored.

Unusual Presentation of Squamous Cell Carcinoma in a Young Male: Clinicopathological Insights and Considerations.

Unlabelled: Cancer of the oral cavity is the most common cancer in males in India, and lip cancer comprises approximately 25% of all oral cancers. Squamous cell carcinoma of lip usually occurs in middle-aged male with history of tobacco use or smoking. Its occurrence in a young, non-smoker male with no associated known predisposing risk factors for carcinoma is very rare.

After silencing suppression: miRNA targets strike back.

Within the continuous tug-of-war between plants and microbes, RNA silencing stands out as a key battleground. Pathogens, in their quest to colonize host plants, have evolved a diverse arsenal of silencing suppressors as a common strategy to undermine the host's RNA silencing-based defenses. When RNA silencing malfunctions in the host, genes that are usually targeted and silenced by microRNAs (miRNAs) become active and can contribute to the reprogramming of host cells, providing an additional defense mechanism.