Publications by authors named "C P Baburajeev"
Article Synopsis
- NF-κB activation is linked to inflammatory diseases, and blocking its pathway is considered a promising treatment for cancers like hepatocellular carcinoma (HCC).
- Researchers synthesized a compound, 3i, which showed strong anti-cancer effects in HCC by inducing cell death.
- The compound works by inhibiting the NF-κB signaling pathway, as evidenced by reduced DNA binding ability of NF-κB and increased apoptosis in treated cells.
The formation of a thrombus is a key event in thromboembolic disorders, that contribute to high mortality and morbidity in affected patients. In the present study, we synthesized a library of novel substituted 3,3-dibutyl-8-methoxy-2,3-dihydrobenzo [b] [1,4] thiazepin-4(5H)-one derivatives which were tested for their platelet aggregation and thrombin inhibitory activity. Among the tested compounds, 3,3-dibutyl-7-(2-chlorophenyl)-8-methoxy-2,3-dihydrobenzo[b] [1,4]thiazepin-4(5H)-one (DCT) displayed the maximum thrombin inhibition with an IC value of 3.
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- Identified heparanase, an enzyme linked to cancer progression, as a promising drug target for cancer treatment.
- Conducted in vitro screening of 150 small molecules with various chemical structures, finding some that inhibit heparanase activity.
- Found that the compound DTP was the most effective heparanase inhibitor and significantly reduced the migration and invasion of cancer cells, indicating its potential for further development in cancer therapy.
The epidermal growth factor receptor (EGFR) is a validated therapeutic target for triple-negative breast cancer (TNBC). In the present study, we synthesize novel adamantanyl-based thiadiazolyl pyrazoles by introducing the adamantane ring to thiazolopyrazoline. On the basis of loss of cell viability in TNBC cells, 4-(adamantan-1-yl)-2-(3-(2,4-dichlorophenyl)-5-phenyl-4,5-dihydro-1-pyrazol-1-yl)thiazole (APP) was identified as a lead compound.
View Article and Find Full Text PDFBcl homologs prominently contribute to apoptotic resistance in cancer cells and serve as molecular targets in treatment of various cancers. Herein, we report the synthesis of biphenyl-adamantane derivatives by a ligand free palladium on carbon based Suzuki reaction using diisopropylamine as a base for the coupling of adamantane based aryl chloride with a variety of aryl boronic acids. Among the biphenyl derivatives synthesized, compound 3'-(adamantan-1-yl)-4'-methoxy-[1,1'-biphenyl]-3-ol (AMB) displayed cytotoxic activity against hepatocellular carcinoma cell lines without significantly affecting the normal cell lines.
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