Publications by authors named "C Oudot"
Introduction: Very rare pediatric tumors (VRTs), defined by an annual incidence ≤2 per million inhabitants, represent a heterogeneous group of cancers. Due to their extremely low incidence, knowledge on these tumors is scant. Since 2012, the French Very Rare Tumors Committee (FRACTURE) database has recorded clinical data about VRTs in France.
View Article and Find Full Text PDFObjective: To obtain a national overview of the epidemiology and management of invasive fungal infections (IFIs) in France for severely immunocompromised children who were treated for acute leukemia or had undergone allogeneic hematopoietic stem cell transplantation (a-HSCT).
Study Design: We performed a national multicenter retrospective study to collect epidemiologic data for proven and probable IFIs in children with acute leukemia under first- line or relapse treatment or who had undergone a-HSCT. We also conducted a prospective practice survey to provide a national overview of IFI management in pediatric hematology units.
Article Synopsis
- The study assessed how well guidelines for early long-term prophylaxis in infants with severe hemophilia A were followed and identified factors impacting this compliance.
- Nearly 333 boys were included, showing a significant increase in prophylaxis use (61.2%) compared to a historical group (9.5%) before the guidelines were implemented.
- Factors like the location of hemophilia treatment centers and age at the time of prophylaxis indication were linked to timely treatment, while early bleeding issues and inhibitor development led to guideline inapplicability in some cases.
- Overall, while the guidelines appear to boost prophylaxis use, challenges in starting treatment early still exist.
Berries are rich sources of (poly)phenols which have been associated with the prevention of cardiovascular diseases in animal models and in human clinical trials. Recently, a berry enriched diet was reported to decrease blood pressure and attenuate kidney disease progression on Dahl salt-sensitive rats. However, the relationship between kidney function, metabolism and (poly)phenols was not evaluated.
View Article and Find Full Text PDFDiets rich in (poly)phenols are associated with a reduced reduction in the incidence of cardiovascular disorders. While the absorption and metabolism of (poly)phenols has been described, it is not clear how their metabolic fate is affected under pathological conditions. This study evaluated the metabolic fate of berry (poly)phenols in an in vivo model of hypertension as well as the associated microbiota response.
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