Publications by authors named "C Osuna"
Premature chondrodermatitis nodularis (adults < 61 years) and infection with human immunodeficiency virus: a matched multi-centre case-control study in North Spain.
Postepy Dermatol Alergol
August 2024
Knowledge, attitudes and perceptions of Latin American healthcare workers relating to antibiotic stewardship and antibiotic use: a cross-sectional multi-country study.
Antimicrob Resist Infect Control
April 2024
Background: The burden of antimicrobial resistance (AMR) in Latin America is high. Little is known about healthcare workers' (HCWs) knowledge, attitudes, and perceptions of antimicrobial stewardship (AS), AMR, and antibiotic use (AU) in the region.
Methods: HCWs from 42 hospitals from 5 Latin American countries were invited to take an electronic, voluntary, anonymous survey regarding knowledge, attitudes, and perceptions of AS, AMR, and AU between March-April 2023.
Article Synopsis
- The study focuses on overcoming the challenge of eradicating the viral reservoir to find a clinical cure for HIV-1 by using a combination of N-803 and broadly neutralizing antibodies (bNAbs) in rhesus macaques that were previously treated with antiretroviral therapy (ART).
- Researchers found that while the treatment induced some immune activation and transient viral levels, it did not significantly lower the viral reservoir. However, about 70% of treated macaques achieved sustained control of the virus after stopping ART.
- The success of viral control was linked to changes in CD8 T cells induced by the combination treatment, suggesting that eliminating the viral reservoir may not be necessary for long-term remission
Mother-to-fetus transmission of the SARS-CoV-2 virus via the placenta has been reported but cannot readily be studied in pregnant women. This protocol describes an in vitro method to investigate SARS-CoV-2 infection of human embryonic stem cells (hESCs), which are similar to epiblast cells in young postimplantation embryos. First, SARS-CoV-2 viral pseudoparticles, which contain the spike protein and a fluorescent reporter, are incorporated into a lentivirus backbone that is expanded in HEK 293T cells.
View Article and Find Full Text PDFSusceptible dogs suffering from canine leishmaniasis (CanL) develop an ineffective humoral immune response that leads to the formation of circulating immune complexes (CIC). These CIC are aggregates of Leishmania proteins and anti-Leishmania immunoglobulins. Their deposition in different tissues is considered the main cause of mortality.
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