Publications by authors named "C Ori"
Article Synopsis
- - This study explores how lung progenitor cells develop from human pluripotent stem cells using advanced techniques like single-cell RNA-sequencing and a refined differentiation protocol.
- - Key findings reveal that specific signaling pathways (Sonic hedgehog, TGF-β, and Notch) are crucial for lung progenitor emergence during the early stages of development, while HHEX influences a separate trajectory that leads to liver cell formation.
- - The research enhances our understanding of how the lungs form and serves as a basis for future research in early human lung development and related modeling using hPSCs.
Placental macrophages are highly heterogeneous cells with differential phenotypes and functions defined by differential origins and modulated by the changing placental environment. During pregnancy, placental macrophages play a critical role in embryo implantation, placenta formation and homeostasis, fetal development and parturition. This review summarizes recent findings on the cellular origin of placental macrophages, and provide a comprehensive description of their phenotypes, corresponding molecular markers and functions in human placenta.
View Article and Find Full Text PDFBackground: Many long noncoding RNAs (lncRNAs) have been implicated in general and cell type-specific molecular regulation. Here, we asked what underlies the fundamental basis for the seemingly random appearance of nuclear lncRNA condensates in cells, and we sought compounds that can promote the disintegration of lncRNA condensates in vivo.
Results: As a basis for comparing lncRNAs and cellular properties among different cell types, we screened lncRNAs in human pluripotent stem cells (hPSCs) that were differentiated to an atlas of cell lineages.
Purpose: Noninvasive ventilation (NIV) may facilitate withdrawal of invasive mechanical ventilation (i-MV) and shorten intensive care unit (ICU) length of stay (LOS) in hypercapnic patients, while data are lacking on hypoxemic patients. We aim to determine whether NIV after early extubation reduces the duration of i-MV and ICU LOS in patients recovering from hypoxemic acute respiratory failure.
Methods: Highly selected non-hypercapnic hypoxemic patients were randomly assigned to receive NIV after early or standard extubation.