Clinical Evaluation of a Multi-Modal Facial Serum That Addresses Hyaluronic Acid Levels in Skin.

Background: Hyaluronic acid (HA), the major glycosaminoglycan present in the human skin, is a key contributor to water retention and mechanical support in skin. The level, size, and functionality of cutaneous HA are known to diminish with age. Topical treatments designed to increase the HA content of skin have been met with limited success.

Use of optical profilometry and visual grading for measurement of longitudinal striations of the nail.

Consumer perception of longitudinal striations of the nail is one of the drivers of nail cosmetic purchase and use. The following work investigates the use of objective instrumental methods for the characterization of longitudinal striations. Striations are quantified by Ra (the average maximum height of the profile), Rq (the root mean square average of the roughness profile), and Rz (the mean roughness depth), industrial roughness parameters, which are calculated using optical profilometry of the three-dimensional surface structure of the nail.

Enhanced efficacy of a topical antioxidants regimen in conjunction with a home-use non-ablative fractional diode laser in photodamaged facial skin.

Background: Photodamaged facial skin is characterized by fine lines and wrinkles, mottled pigmentation, and other changes.

Objective: To evaluate and compare the efficacy and tolerance of a home-use laser device when used alone or in combination with an antioxidant facial treatment for moderate photodamage.

Methods: This was a 49-subject, evaluator-blinded, split-face, randomized, single-center, 24-week, phase-2, study.