Publications by authors named "C Onnie"
Article Synopsis
- The study examines the effectiveness of sequential drug treatments for ulcerative colitis (UC), specifically comparing the use of vedolizumab (VDZ) and anti-TNF therapies as second-line treatments.
- Researchers analyzed data from patients who switched treatments between May 2013 and August 2020, looking at various health outcomes over a 52-week period.
- Results indicated that patients receiving VDZ after anti-TNF had significantly better treatment persistence, colectomy-free survival, and clinical remission compared to those receiving anti-TNF after VDZ, suggesting a favorable effect of the treatment order on patient outcomes.
Background: TGR5, the G protein-coupled bile acid receptor 1 (GPBAR1), has been linked to inflammatory pathways as well as bile homeostasis, and could therefore be involved in primary sclerosing cholangitis (PSC) a chronic inflammatory bile duct disease. We aimed to extensively investigate TGR5 sequence variation in PSC, as well as functionally characterize detected variants.
Methodology/principal Findings: Complete resequencing of TGR5 was performed in 267 PSC patients and 274 healthy controls.
We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P(rs7809799) = 8.81 x 10(-11) and P(rs5771069) = 4.
View Article and Find Full Text PDFDNA polymorphisms in a region on chromosome 5q33.1 which contains two genes, immunity related GTPase related family, M (IRGM) and zinc finger protein 300 (ZNF300), are associated with Crohn's disease (CD). The deleted allele of a 20 kb copy number variation (CNV) upstream of IRGM was recently shown to be in strong linkage disequilibrium (LD) with the CD-associated single nucleotide polymorphisms and is itself associated with CD (P < 0.
View Article and Find Full Text PDF