Publications by authors named "C Onal"
Background: Tumor suppressors are well known drivers of cancer invasion and metastasis in metastatic castration sensitive prostate cancer (mCSPC). However, oncogenes are also known to be altered in this state, however the frequency and prognosis of these alterations are unclear. Thus, we aimed to study the spectrum of oncogene mutations in mCSPC and study the significance of these alteration on outcomes.
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- This study explored the use of diffusion-weighted MRI to evaluate prostate cancer patients with Gleason score 7 tumors before radiotherapy, focusing on the correlation between MRI results, cancer characteristics, and treatment outcomes.
- It was found that tumors classified as GS 3+4 had higher ADC values compared to GS 4+3 tumors, indicating a difference in disease aggression, with lower ADC values linked to poorer survival rates.
- The research concluded that ADC values could serve as an effective biomarker to distinguish between different types of GS 7 tumors, with lower values correlating with a higher risk of disease progression and worse long-term outcomes.
Article Synopsis
- - There is a need for better tools to help manage oligometastatic castration-sensitive prostate cancer (omCSPC), as highlighted in a retrospective study examining the effectiveness of the ArteraAI Prostate Test.
- - This study involved 222 men and measured outcomes like overall survival (OS) and time until the cancer becomes castration-resistant, finding a high MMAI score linked to worse OS and shorter time to resistance.
- - Additionally, the study indicated that patients with high MMAI scores who received metastasis-directed therapy (MDT) had improved metastasis-free survival compared to those with low scores, pointing to the potential of the MMAI biomarker for guiding treatment decisions.
Article Synopsis
- The study evaluated the outcomes of younger (< 70 years) and older (≥ 70 years) prostate cancer patients after receiving definitive radiotherapy, focusing on disease-free survival and side effects.
- Findings showed similar 7-year biochemical disease-free survival and prostate cancer-specific survival rates between the two age groups, despite older patients having additional risk factors and comorbidities.
- The research concluded that definitive radiotherapy is a safe and effective treatment for localized prostate cancer regardless of age, as older patients experience comparable rates of survival and toxicity to younger ones.
Objective: This study compared the efficacy of ultrasound-guided erector spinae plane block (ESPB) and wound infiltration (WI) for postoperative analgesia in patients who underwent lumbar spinal surgery with instrumentation.
Methods: In this randomized controlled trial, 80 patients were divided into two groups: ESPB (n = 40) and WI (n = 40). Postoperative pain intensity was assessed via the visual analog scale (VAS) at multiple time points within 24 h.