Ultrastructural Analysis Reveals Mitochondrial Placement Independent of Synapse Placement in Fine Caliber C. elegans Neurons.

Neurons rely on mitochondria for an efficient supply of ATP and other metabolites. However, while neurons are highly elongated, mitochondria are discrete and limited in number. Due to the slow rates of metabolite diffusion over long distances, it follows that neurons would benefit from an ability to control the distribution of mitochondria to sites of high metabolic activity such as synapses.

Bichromatic exon-reporters reveal voltage-gated Ca -channel splice-isoform diversity across neurons .

Every neuron contains the same genomic information but its complement of proteins is the product of countless neuron-specific steps including pre-mRNA splicing. Despite advances in RNA sequencing techniques, pre-mRNA splicing biases that favor one isoform over another are largely inscrutable in live neurons . Here, in , we developed bichromatic fluorescent reporters to investigate alternate splicing of - a gene that codes the pore-forming α -subunit of the primary neuronal voltage-gated Ca channel (VGCC).

BRIDGING THE GAP - EARLY COMMUNITY OUTREACH AS AN INITIATIVE TO INCREASE REPRESENTATION IN RADIOLOGY.

Rationale And Objectives: Underrepresentation of minorities is a worsening issue in the field of radiology. Early educational interventions are a promising approach to mitigating this disparity. We present an approach for a radiology department to increase community outreach via establishment of an educational program for local public high school students and building a mentorship pipeline for radiology education.

Sperm Storage and Use Following Multiple Insemination in Encouraging Insights for the Sterile Insect Technique.

The key to success in the application of the sterile insect technique (SIT) relies on the ability of released, sterile males to outcompete their fertile wild male counterparts to mate with wild females. However, many insect species exhibit multiple-mating behavior, which can be a way for females to select paternity for their progeny. This study aims to recognize the consequences of potential double-matings during an SIT program and to detect any evidence of sperm selection favoring sperm from fertile mates.

cIAP-2 protein is upregulated by human papillomavirus in oropharyngeal cancers: role in radioresistance in vitro.

Background: High-risk human papillomaviruses are the causal agents of a subset of head and neck cancers. A previous transcriptomic analysis showed that cIAP2 protein, involved in cell survival and apoptosis, is upregulated in OKF6 oral cells that express HPV16 E6/E7. In addition, cIAP2 promotes radioresistance, a very important concern in HNC treatment.