Publications by authors named "C Odom"
Article Synopsis
- The study highlights the importance of identifying host factors in pneumonia to improve treatment strategies.
- LOX-1, a receptor known for causing inflammation, has been found to accumulate in the lungs during pneumonia but functions protectively by limiting inflammation and edema.
- The research suggests that macrophages and neutrophils express LOX-1, with its blockade causing immune dysregulation, indicating LOX-1's critical role in lung protection during pneumonia.
Objectives: The purpose of this study was to identify the patient, injury, and treatment factors associated with infection of bicondylar plateau fractures and to evaluate whether center variation exists.
Design: Retrospective review.
Setting: Eighteen academic trauma centers.
Epithelial LIF signaling limits apoptosis and lung injury during bacterial pneumonia.
Am J Physiol Lung Cell Mol Physiol
April 2022
During bacterial pneumonia, alveolar epithelial cells are critical for maintaining gas exchange and providing antimicrobial as well as pro-immune properties. We previously demonstrated that leukemia inhibitory factor (LIF), an IL-6 family cytokine, is produced by type II alveolar epithelial cells (ATII) and is critical for tissue protection during bacterial pneumonia. However, the target cells and mechanisms of LIF-mediated protection remain unknown.
View Article and Find Full Text PDFRecovery from pneumococcal pneumonia remodels the pool of alveolar macrophages so that they exhibit new surface marker profiles, transcriptomes, metabolomes, and responses to infection. Mechanisms mediating alveolar macrophage phenotypes after pneumococcal pneumonia have not been delineated. IFN-γ and its receptor on alveolar macrophages were essential for certain, but not all, aspects of the remodeled alveolar macrophage phenotype.
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