Publications by authors named "C O"
Article Synopsis
- Monogenic diabetes results from rare gene mutations affecting beta cell function, and this study examines how common variants may also influence young-onset type 2 diabetes (YOD) and related health issues.
- Researchers created a weighted polygenic risk score (wPRS) using data from individuals with and without YOD to explore the association of 135 common variants across 34 monogenic diabetes genes.
- The findings indicate that higher wPRS correlates with an increased likelihood of YOD and a higher risk for cardiovascular and kidney events in individuals with type 2 diabetes.
Article Synopsis
- A new patient-centered, data-driven care model was developed and implemented to improve clinical outcomes for patients with young-onset type 2 diabetes (T2D), an area lacking well-established practice guidelines.
- The study, part of a 3-year randomized controlled trial, involves a team-based management approach utilizing genetic markers and technology to tailor treatments for individuals diagnosed with T2D before the age of 40.
- Out of 884 participants, those in the specialized JADE-PRISM group received more focused care, showing the potential for better management of complications and treatment goals compared to standard care protocols.
Young-Onset Diabetes in East Asians: From Epidemiology to Precision Medicine.
Endocrinol Metab (Seoul)
April 2024
Precision diagnosis is the keystone of clinical medicine. In East Asians, classical type 1 diabetes is uncommon in patients with youngonset diabetes diagnosed before age of 40, in whom a family history, obesity, and beta-cell and kidney dysfunction are key features. Young-onset diabetes affects one in five Asian adults with diabetes in clinic settings; however, it is often misclassified, resulting in delayed or non-targeted treatment.
View Article and Find Full Text PDFAims: To examine the risk association of insomnia with incident chronic cognitive impairment in older adults with type 2 diabetes mellitus (T2D).
Methods: Between July 2010 and June 2015, patients with T2D aged ≥60 years enrolled in the Hong Kong Diabetes Register completed the Insomnia Severity Index (ISI) questionnaire. Patients were considered having insomnia if they had ISI score > 14.