Publications by authors named "C O Poulsen"
ARGONAUTE (AGO) proteins bind to small non-coding RNAs to form RNA-induced silencing complexes. In the RNA-bound state, AGO is stable while RNA-free AGO turns over rapidly. Molecular features unique to RNA-free AGO that allow its specific recognition and degradation remain unknown.
View Article and Find Full Text PDFIntegrated mental health care and vocational rehabilitation intervention to improve return to work rates for people on sick leave due to common mental and functional disorders (IBBIS-II) - results from a randomized clinical trial.
Nord J Psychiatry
January 2025
Article Synopsis
- Over 50% of long-term sickness benefit recipients in Denmark suffer from common mental illness, with less than 30% receiving adequate treatment.
- A trial assigned 900 participants with mental illness to either an integrated health and vocational care program (IBBIS II) or standard service, measuring return to work (RTW) after 12 months.
- Results showed no significant difference in RTW between IBBIS II and standard service, with IBBIS II possibly leading to worse employment outcomes; therefore, its widespread implementation is not recommended.
Introduction: Individuals with type 1 diabetes (T1D) and diabetic nephropathy (DN) experience progressive kidney function decline and high risk of cardiovascular disease (CVD) and mortality. This study explored changes in kidney function decline in new-onset DN between 2000 and 2020 and provided an updated prognosis for risk of kidney failure, CVD, and mortality.
Methods: This is a register-based cohort study in T1D with new-onset DN (severely increased albuminuria) between 2000 and 2020 at Steno Diabetes Center Copenhagen, Denmark.
Background: The gut microbiota has been implicated in adult obesity, but the causality is still unclear. It has been hypothesized that an obesity-prone gut microbiota can be established in infancy, but only few studies have examined the early-life gut microbiota in relation to obesity in childhood, and no consistent associations have been reported. Here, we examine the association between the early-life gut microbiota and body mass index (BMI) development and body composition throughout childhood.
View Article and Find Full Text PDF