Therapeutic Flecainide Toxicity Causing VT Storm.

Ventricular tachycardia (VT) storm is a fatal arrhythmia with multiple contributory etiologies. This paper presents a case of a 71-year-old woman who developed VT storm from flecainide toxicity occurring at therapeutic flecainide levels. Flecainide toxicity should be considered in any patient on flecainide presenting with VT.

New evidence for early Indian Ocean trade routes into the South African interior.

The rise and spread of ancient Indian Ocean Rim (IOR) trade networks profoundly impacted southern Africa. Control over this trade played a critical role in the rise and maintenance of complex societies of the second millennium CE such as Mapungubwe and Great Zimbabwe. While the African origins of this trade lie in the first millennium CE, understanding its earliest phases and subsequent development in the far south has been hampered by a general paucity of research.

Contribution of Nuclear Fragmentation to Dose and RBE in Carbon-Ion Radiotherapy.

Variable relative biological effectiveness (RBE) of carbon radiotherapy may be calculated using several models, including the microdosimetric kinetic model (MKM), stochastic MKM (SMKM), repair-misrepair-fixation (RMF) model, and local effect model I (LEM), which have not been thoroughly compared. In this work, we compared how these four models handle carbon beam fragmentation, providing insight into where model differences arise. Monoenergetic and spread-out Bragg peak carbon beams incident on a water phantom were simulated using Monte Carlo.