Publications by authors named "C O Nwosu"
Hydrogen sulfide (HS) donors are emerging as promising candidates for neuroprotective agents. However, HS-dependent neuroprotective mechanisms are not yet fully understood. We have demonstrated that an HS donor (sodium sulfide, NaS) reduces the expression of inducible NO synthase (iNOS) and amyloid-beta precursor protein (APP) in damaged neural tissue at 24 h and 7 days following traumatic brain injury (TBI).
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- Acne vulgaris, the most common skin disorder, primarily affects adolescents and can significantly impact self-esteem and mental well-being despite being generally non-harmful to health.
- Its main causes include overactive sebaceous glands influenced by androgens and the presence of Cutibacterium acnes bacteria.
- Standard treatments range from topical options to systemic medications, which can have side effects, leading to interest in alternative therapies like laser and light-based treatments, including a newly FDA-approved 1,726 nm laser. *
Background: Mortality associated with neonatal surgical emergencies is high, due to late presentation and delayed surgical intervention in developing countries. The aim of this study is to determine factors associated with poor outcome of neonatal surgical emergencies at a Federal Teaching Hospital Northeastern Nigeria.
Methods: A retrospective study of 85 neonates aged 1-28 days was carried between June 2019-May 2022.
Background: Hydroxyurea is an evidence-based disease-modifying therapy for sickle cell disease (SCD) but is underutilized. The Integration of Mobile Health into Sickle Cell Disease Care to Increase Hydroxyurea Utilization (meSH) multicenter study leveraged mHealth to deliver targeted interventions to patients and providers. SCD studies often underenroll; and recruitment strategies in the SCD population are not widely studied.
View Article and Find Full Text PDFBackground: Obesity as a disorder with excess body fat directly decreases quality of life. While Body Mass Index (BMI) has been used largely in health studies as a measure of obesity, it is largely unable to differentiate between body fat and lean body mass, hence other anthropometric measures can be used to assess body fat.
Objective: To determine the association of anthropometric indicators with health-related quality of life (HRQoL) in obese adults.