Publications by authors named "C O'Dowd"
Article Synopsis
- Atmospheric new particle formation (NPF) is the natural process of creating tiny particles (sub-10 nm) from gases, observed globally in various environments.
- Although these particles impact total and ultrafine particle concentrations, there is limited research on their health effects largely due to a lack of specific identifiers in existing data.
- This study introduces an automated machine learning algorithm that identifies NPF events from particle data across 65 global measurement sites from 1996 to 2023, facilitating future research on NPF.
Under the EU Air Quality Directive (AQD) 2008/50/EC member states are required to undertake routine monitoring of PM composition at background stations. The AQD states for PM speciation this should include at least: nitrate , sulfate , chloride (Cl), ammonium (NH4), sodium (Na), potassium (K), magnesium (Mg), calcium (Ca), elemental carbon (EC) and organic carbon (OC). Until 2017, it was the responsibility of each country to determine the methodology used to report the composition for the inorganic components of PM.
View Article and Find Full Text PDFBackground: Understanding how to modulate the microenvironment of tumors that are resistant to immune checkpoint inhibitors represents a major challenge in oncology.Here we investigate the ability of USP7 inhibitors to reprogram the tumor microenvironment (TME) by inhibiting secretion of vascular endothelial growth factor (VEGF) from fibroblasts.
Methods: To understand the role played by USP7 in the TME, we systematically evaluated the effects of potent, selective USP7 inhibitors on co-cultures comprising components of the TME, using human primary cells.
Global warming is now universally acknowledged as being responsible for dramatic climate changes with rising sea levels, unprecedented temperatures, resulting fires and threatened widespread species loss. While these effects are extremely damaging, threatening the future of life on our planet, one unexpected and paradoxically beneficial consequence could be a significant contribution to global iodine supply. Climate change and associated global warming are not the primary causes of increased iodine supply, which results from the reaction of ozone (O3) arising from both natural and anthropogenic pollution sources with iodide (I-) present in the oceans and in seaweeds (macro- and microalgae) in coastal waters, producing gaseous iodine (I2).
View Article and Find Full Text PDFGhana 3D Telemedicine International MDT: A proof-of-concept study.
J Plast Reconstr Aesthet Surg
January 2024
Article Synopsis
- A real-time 3D Telemedicine system was developed using Microsoft’s Holoportation™ to facilitate international medical team meetings for complex reconstructive surgeries, enabling pre, during, and post-surgical consultations.
- A proof-of-concept clinic involving UK and Ghanaian medical facilities assessed patients and surgical plans, providing a 3D visual experience for patients and enhancing logistical discussions.
- Feedback from participants indicated high satisfaction and usability ratings, demonstrating the potential for this technology to improve surgical collaboration and patient care in low-to-middle-income countries.