No evidence of Chlamydia pneumoniae in the synovia of patients with osteoarthritis.

Objective: Osteoarthritis (OA) is a common cause of disability affecting millions of people of all ages worldwide. The pathogenesis involves an inflammatory component, but the cause of the inflammation remains incompletely understood. The intracellular bacteria Chlamydia trachomatis and C.

Iron Homeostasis in Tissues Is Affected during Persistent Infection in Mice.

may be a mediator in the pathogenesis of atherosclerosis. For its growth depends on iron (Fe), but how Fe changes in tissues during persistent infection or affects bacterial replication in tissues is unknown. -infected C57BL/6J mice were sacrificed on days 4, 8, 20, and 40.

Cholesterol uptake in the mouse aorta increases during Chlamydia pneumoniae infection.

Chlamydia pneumoniae has been suggested as a stimulator of the atherosclerotic process. Mice fed a normal diet were infected intranasally with C. pneumoniae and given one intraperitoneal injection of 14C-cholesterol tracer per day for 12 days.

Trace Element Changes in Thoracic Aortic Dissection.

Thoracic aortic dissection is a life-threatening condition with an incompletely understood pathogenesis. Trace elements are essential for the functioning of different processes in the body, including the immune system and associated responses to infection/inflammation. Because inflammation may be part of the pathogenesis of thoracic aortic dissection, we investigated whether trace element changes associated with inflammation occur in serum and tissue samples during the disease.