Publications by authors named "C Noviello"

Lymphatic Malformations (LMs) are benign congenital malformations of the lymphatic system that commonly involve the abdomen in children (mesentery of the small intestine and omentum). The management of these malformations is not unique. 7 children with different ages (range: newborn to 14 years), diagnosis was incidental in some cases, while in others for abdominal pain.

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Type A GABA (γ-aminobutyric acid) receptors (GABA receptors) mediate most fast inhibitory signalling in the brain and are targets for drugs that treat epilepsy, anxiety, depression and insomnia and for anaesthetics. These receptors comprise a complex array of 19 related subunits, which form pentameric ligand-gated ion channels. The composition and structure of native GABA receptors in the human brain have been inferred from subunit localization in tissue, functional measurements and structural analysis from recombinant expression and in mice.

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Article Synopsis
  • Autoimmune autonomic ganglionopathy (AAG) is a rare disease where the body mistakenly attacks a type of receptor called gAChR.
  • Doctors in the U.S. usually diagnose AAG by checking for symptoms and testing for specific autoantibodies with a method called a radioimmunoprecipitation assay (RIA).
  • This study suggests a new testing method called fluorescence-detection size-exclusion-chromatography (FSEC) that can also find these autoantibodies, showing it might be a good option for diagnosing AAG.
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IL-10 autoantibodies are detected in two patients with severe inflammatory bowel disease.

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Gynecomastia is a benign glandular proliferation that can affect adolescents causing significant psychological discomfort. Generally, it is idiopathic but underlying endocrinological conditions must be excluded. Different surgical techniques are available, the surgical correction with subareolar incision achieves the goal of satisfactory aesthetic result for patients.

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