Snow cover phenology dataset over global mountain regions from 2000 to 2023.

Monitoring temporal and spatial changes in the mountain seasonal snowpack is a key step to better quantify the impact of recent climate warming on this very sensitive environment. In this context, to support the research on large scale, there is an urgent need of consistent and accurate data sets over global mountain regions. This paper presents a dataset derived from Moderate Resolution Imaging Spectroradiometer (MODIS) imagery collection 6.

The exon junction complex is required for DMD gene splicing fidelity and myogenic differentiation.

Deposition of the exon junction complex (EJC) upstream of exon-exon junctions helps maintain transcriptome integrity by preventing spurious re-splicing events in already spliced mRNAs. Here we investigate the importance of EJC for the correct splicing of the 2.2-megabase-long human DMD pre-mRNA, which encodes dystrophin, an essential protein involved in cytoskeletal organization and cell signaling.

Overall negative trends for snow cover extent and duration in global mountain regions over 1982-2020.

Notwithstanding the large availability of data and models, a consistent picture of the snow cover extent and duration changes in global mountain areas is lacking for long-term trends. Here, model data and satellite images are combined by using Artificial Neural Networks to generate a consistent time series from 1982 to 2020 over global mountain areas. The analysis of the harmonized time series over 38 years indicates an overall negative trend of - 3.

Skeletal Ryanodine Receptors Are Involved in Impaired Myogenic Differentiation in Duchenne Muscular Dystrophy Patients.

Duchenne muscular dystrophy (DMD) is characterized by progressive muscle wasting following repeated muscle damage and inadequate regeneration. Impaired myogenesis and differentiation play a major role in DMD as well as intracellular calcium (Ca) mishandling. Ca release from the sarcoplasmic reticulum is mostly mediated by the type 1 ryanodine receptor (RYR1) that is required for skeletal muscle differentiation in animals.

Prevention of vascular calcification by the endogenous chromogranin A-derived mediator that inhibits osteogenic transdifferentiation.

The adrenal glands participate in cardiovascular (CV) physiology and the pathophysiology of CV diseases through their effects on sodium and water metabolism, vascular tone and cardiac function. In the present study, we identified a new adrenal compound controlling mesenchymal cell differentiation that regulates osteoblastic differentiation in the context of vascular calcification. This peptide was named the "calcification blocking factor" (CBF) due to its protective effect against vascular calcification and is released from chromogranin A via enzymatic cleavage by calpain 1 and kallikrein.