Publications by authors named "C Niek Van Dijk"
Background: Previous spontaneous preterm birth (sPTB) is a strong risk indicator for recurrent preterm birth (PTB). Cervical cerclage is an accepted intervention to prevent recurrent PTB in high risk patients. Cervical pessary might be a less invasive alternative.
View Article and Find Full Text PDFAtherosclerosis on a Chip: A 3-Dimensional Microfluidic Model of Early Arterial Events in Human Plaques.
Arterioscler Thromb Vasc Biol
December 2024
Article Synopsis
- - This study aimed to create a realistic 3D model of human atherosclerosis by coculturing different cell types, including smooth muscle cells and foam cells, to mimic a diseased blood vessel and study immune cell interactions under flow conditions.
- - Researchers developed a specialized coculture protocol using fluorescently labeled human cells and examined how these cells behaved in normal vs. atherosclerotic vessel environments over 24 hours of perfusion.
- - Results showed the model formed early atherosclerotic lesions, with distinct layers and foam cell accumulation, while circulating immune cells (THP-1 monocytes) exhibited movement into the vessel walls and responded to atherosclerosis-related signals.