A Novel Bioluminescent Biosensor Quantifying Intramolecular Interaction and Levels of Pyroptosis Effector GSDMD.

Gasdermin D (GSDMD) is a key executor of pyroptosis, a form of inflammation-induced programmed cell death. Recently, GSDMD has been shown to play important roles in the development of various inflammatory-related human diseases including heart failure and cancer, suggesting that it is a promising therapeutic target for these diseases. While extensive studies on GSDMD's role in pyroptosis have been reported, it is challenging to study its function due to the lack of enzymatic activity of GSDMD.

New insights into muscle activity associated with phantom hand movements in transhumeral amputees.

Introduction: Muscle activity patterns in the residual arm are systematically present during phantom hand movements (PHM) in transhumeral amputees. However, their characteristics have not been directly investigated yet, leaving their neurophysiological origin poorly understood. This study pioneers a neurophysiological perspective in examining PHM-related muscle activity patterns by characterizing and comparing them with those in the arm, forearm, and hand muscles of control participants executing intact hand movements (IHM) of similar types.

Patient reported outcomes and short-term adjustment trajectories following gamma knife radiosurgery for benign brain tumor.

Purpose: Patient reported outcomes (PROs) in the context of Gamma Knife Stereotactic Radiosurgery (GKSRS) for benign brain tumor have been under-researched. This study examined changes in PROs and adjustment trajectories post-GKSRS.

Method: 50 adults (54% female) aged on average 53.

Towards a more individualised assessment of post-training fatigue in young footballers.

Despite improvements in training load and fatigue monitoring, fatigue status may adversely affect intrinsic risk factors, particularly in young footballers. This study aimed to better individualise the fatigue effects of a 75-min football training session in young elite male players. Eighteen players (15.