Publications by authors named "C Newgard"
Objective: Among children transported by ambulance across the United States, we used machine learning models to develop a risk prediction tool for firearm injury using basic demographic information and home ZIP code matched to publicly available data sources.
Methods: We included children and adolescents 0-17 years transported by ambulance to acute care hospitals in 47 states from January 1, 2014 through December 31, 2022. We used 96 predictors, including basic demographic information and neighborhood measures matched to home ZIP code from 5 data sources: EMS records, American Community Survey, Child Opportunity Index, County Health Rankings, and Social Vulnerability Index.
Article Synopsis
- Endurance exercise training (ExT) leads to significant changes in lipid composition across various tissues, highlighting the need for a deeper understanding of these alterations.
- In a study involving Fischer-344 rats, it was found that both male and female rats show distinct lipid remodeling in tissues like the heart, liver, and skeletal muscle after different durations of ExT.
- Exercise resulted in lower body fat and better cardiorespiratory fitness, with important changes in types of lipids (like phospholipids and ceramides) that could help explain how exercise benefits overall health.
Importance: High emergency department (ED) pediatric readiness is associated with improved survival among children receiving emergency care, but state and national costs to reach high ED readiness and the resulting number of lives that may be saved are unknown.
Objective: To estimate the state and national annual costs of raising all EDs to high pediatric readiness and the resulting number of pediatric lives that may be saved each year.
Design, Setting, And Participants: This cohort study used data from EDs in 50 US states and the District of Columbia from 2012 through 2022.
Article Synopsis
- The study investigates how SGLT2 inhibitors, particularly dapagliflozin, affect metabolism in patients with heart failure (HF) differing by ejection fraction (EF), focusing on ketone and fatty acid changes.
- It analyzed data from two trials involving 527 participants, using metabolomic profiling to identify the effects of dapagliflozin on various metabolites over 12 weeks.
- The findings revealed that dapagliflozin increased certain metabolites associated with ketosis and acylcarnitines but had less effect on amino acids, showing varying impacts depending on the patient's left ventricular ejection fraction.
The quality of emergency department (ED) care for children in the US is highly variable. The National Pediatric Readiness Project aims to improve survival for children receiving emergency services. We conducted a cost-effectiveness analysis of increasing ED pediatric readiness, using a decision-analytic simulation model.
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