Publications by authors named "C Newcomb"
Article Synopsis
- The study aimed to create a Hepatotoxicity Score to better evaluate the safety of medications affecting the liver, considering the challenge posed by the simultaneous use of other harmful drugs.
- Researchers analyzed data from the Veterans Health Administration from 2000 to 2021, focusing on 193 medications linked to liver issues and monitoring hospitalization rates for severe liver injuries.
- Results showed that adjusting for the Hepatotoxicity Score altered the perceived risks of specific drugs like lansoprazole and pantoprazole when compared to omeprazole, suggesting the score can help clarify drug safety in real-world scenarios.
Importance: High-risk practices, including dispensing an opioid prescription before surgery when not recommended, remain poorly characterized among US youths and may contribute to new persistent opioid use.
Objective: To characterize changes in preoperative, postoperative, and refill opioid prescriptions up to 180 days after surgery.
Design, Setting, And Participants: This retrospective cohort study was performed using national claims data to determine opioid prescribing practices among a cohort of opioid-naive youths aged 11 to 20 years undergoing 22 inpatient and outpatient surgical procedures between 2015 and 2020.
Importance: Current approaches to classify the hepatotoxic potential of medications are based on cumulative case reports of acute liver injury (ALI), which do not consider the size of the exposed population. There is little evidence from real-world data (data relating to patient health status and/or the delivery of health care routinely collected from sources outside of a research setting) on incidence rates of severe ALI after initiation of medications, accounting for duration of exposure.
Objective: To identify the most potentially hepatotoxic medications based on real-world incidence rates of severe ALI and to examine how these rates compare with categorization based on case reports.
Purpose: To evaluate the incidence, remission, and relapse of post-surgical cystoid macular edema (PCME) following cataract surgery in inflammatory eye disease.
Methods: A total of 1859 eyes that had no visually significant macular edema prior to cataract surgery while under tertiary uveitis management were included. Standardized retrospective chart review was used to gather clinical data.
Article Synopsis
- A study evaluated the incidence of significant posterior capsule opacification (PCO) and YAG laser capsulotomy among uveitic eyes after cataract surgery, revealing that about 16% of eyes experienced PCO with reduced visual acuity within a year.* -
- Analysis of 1,855 uveitic eyes found that younger patients, those with poorer preoperative vision, and postoperative inflammation were more likely to develop PCO, while younger age and female sex were risk factors for needing YAG laser capsulotomy.* -
- The findings indicate that PCO is common in uveitic patients post-surgery, with 22% of eyes undergoing YAG laser treatment in the same timeframe, emphasizing the need for