Publications by authors named "C Neveu"
Article Synopsis
- Mayotte, a small tropical island in the Comoros, has become a French department but relies heavily on imported food, highlighting the need for local livestock farming development.
- Interviews with 15 farmers revealed major challenges, including limited land access for raising animals, water scarcity, and inadequate road infrastructure impacting farm operations.
- Additional obstacles include dependence on imported animal feed and livestock, lack of organized local food systems, and financial constraints; while animal health issues are present, farmers tend to favor traditional medicine over seeking veterinary care.
The human louse () is an obligatory blood feeding ectoparasite with two ecotypes: the human body louse (), a competent vector of several bacterial pathogens, and the human head louse (), responsible for pediculosis and affecting millions of people around the globe. GABA (γ-aminobutyric acid) receptors, members of the cys-loop ligand gated ion channel superfamily, are among the main pharmacological targets for insecticides. In insects, there are four subunits of GABA receptors: resistant-to-dieldrin (RDL), glycin-like receptor of drosophila (GRD), ligand-gated chloride channel homologue3 (LCCH3), and 8916 are well described and form distinct phylogenetic clades revealing orthologous relationships.
View Article and Find Full Text PDFThe ascarids are a large group of parasitic nematodes that infect a wide range of animal species. In humans, they cause neglected diseases of poverty; many animal parasites also cause zoonotic infections in people. Control measures include hygiene and anthelmintic treatments, but they are not always appropriate or effective and this creates a continuing need to search for better ways to reduce the human, welfare and economic costs of these infections.
View Article and Find Full Text PDFFunctional validation of novel levamisole resistance marker S168T in Haemonchus contortus.
Int J Parasitol Drugs Drug Resist
April 2024
Article Synopsis
- A variant called S168T in the ACR-8 subunit of acetylcholine receptors has been linked to resistance against the drug levamisole in the parasitic worm Haemonchus contortus.
- Using a specialized system involving Xenopus laevis oocytes and voltage-clamp techniques, researchers found that the S168T variant decreased the response of the L-AChR-1.1 receptor to levamisole, making it less effective.
- These findings indicate that the S168T mutation is crucial in understanding how levamisole resistance occurs at the receptor level.
Article Synopsis
- Neurons can be categorized based on their firing patterns, with some exhibiting regular firing that depends on stimulus strength, while others show all-or-nothing plateau potentials that maintain activity independent of the stimulus.
- In a study of three identified neurons (B51, B64, and B8), B51 and B64 generated plateau potentials, while B8 fired regularly without producing plateau potentials, despite having similar types of electrical currents.
- Key factors influencing the generation of plateau potentials include the interaction between incoming currents (like persistent Na) and outgoing currents (like delayed outward current), rather than the presence of any single type of ion channel; techniques for predicting neuronal properties were also developed.