Publications by authors named "C Nettles"

The Society for Community Research and Action (SCRA) is the primary professional home for community psychologists in the United States and increasingly around the world. Since the formation of the American Psychological Association Division 27: Community Psychology in 1966, now SCRA, 54 people have served in the Presidential role. Presidential leaders' annual addresses both reflect the current state of the field and have the ability to shape the future of both SCRA as an organization and community psychology as a discipline given their positions as leaders.

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Efforts to improve estrogen receptor-α (ER)-targeted therapies in breast cancer have relied upon a single mechanism, with ligands having a single side chain on the ligand core that extends outward to determine antagonism of breast cancer growth. Here, we describe inhibitors with two ER-targeting moieties, one of which uses an alternate structural mechanism to generate full antagonism, freeing the side chain to independently determine other critical properties of the ligands. By combining two molecular targeting approaches into a single ER ligand, we have generated antiestrogens that function through new mechanisms and structural paradigms to achieve antagonism.

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Article Synopsis
  • Glucocorticoids are effective anti-inflammatories but can cause side effects like insulin resistance and muscle loss.
  • Researchers used a method called ligand class analysis to study different ligands that adjust glucocorticoid receptor activity in various ways, revealing different effects on muscle glucose usage and protein balance.
  • Their findings showed that some ligands promote beneficial effects, like preserving muscle function and enhancing protein synthesis, without causing muscle atrophy, suggesting this research method could apply to other receptor systems as well.
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In prior research, having traits consistent with a personality disorder has been shown to be related to substance use and high-risk sexual activity; however, few studies have examined relationships between dependency traits and health-jeopardizing behaviors. Individuals with traits consistent with dependent personality disorder may be more likely to be in a primary relationship characterized by unhealthy conditions, including physical abuse from a partner, low assertiveness in sexual situations, and partner infidelity. In addition, dependency traits may be associated with unhealthy coping (e.

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Superparamagnetic relaxometry (SPMR) is a highly sensitive technique for the in vivo detection of tumor cells and may improve early stage detection of cancers. SPMR employs superparamagnetic iron oxide nanoparticles (SPION). After a brief magnetizing pulse is used to align the SPION, SPMR measures the time decay of SPION using super-conducting quantum interference device (SQUID) sensors.

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