Publications by authors named "C Neagoe"
Breast cancer remains one of the leading causes of death among women worldwide, and recent research highlights its growing connection to alterations in the microbiota. This review delves into the intricate relationship between microbiotas and breast cancer, exploring its presence in healthy breast tissue, its changes during cancer progression, and its considerable impact on both the tumor microenvironment (TME) and the tumor immune microenvironment (TIME). We extensively analyze how the microbiota influences cancer growth, invasion, metastasis, resistance to drugs, and the evasion of the immune system, with a special focus on its effects on the TIME.
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- - Hereditary angioedema (HAE) is a rare genetic disorder affecting about 1 in 50,000 to 1 in 150,000 people globally, characterized by recurrent episodes of non-itchy swelling, without significant variation among genders or ethnicities.
- - There are three types of HAE: Type I (85% of cases) involves a deficiency in the C1 esterase inhibitor gene, Type II (15%) features dysfunctional C1-INH, and Type III (5-10%) is often estrogen-dependent with normal C1-INH levels, but all types show similar symptoms.
- - Recent advancements in understanding HAE have led to the development of targeted therapies for both immediate treatment
Background/objectives: Fibromyalgia (FM) affects up to 5% of the global population and is a leading cause of significant social and economic consequences. Higher health literacy leads to better understanding of treatment plans, improved self-care, and adherence to recommendations, enhancing overall quality of life. This study aims to determine whether different aspects of the disease are influenced by patients' education level and literacy when applying the same therapy and to assess how patients' perceptions of therapy outcomes vary over time based on their educational level.
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- Paraneoplastic syndromes involve clinical symptoms caused by substances released by cancer cells, with paraneoplastic glomerulopathy specifically relating to kidney issues linked to malignancies, especially solid tumors.
- The case study presents a 44-year-old male with nephrotic syndrome symptoms such as edema and high protein levels in urine, which led to further investigations for an underlying cancer.
- Colonoscopy revealed a polyp, and a biopsy confirmed adenocarcinoma, illustrating how nephrotic syndrome can serve as a crucial indicator for early cancer detection.
Significant gaps remain in the understanding of the etiology and pathogenesis of fibromyalgia (FM), and the COVID-19 pandemic has introduced even more unknowns. Social factors specific to that period, the viral infection itself, and/or vaccination are additional elements that can complicate the progression of the disease or the response to treatment. Aim: The primary hypothesis to be evaluated in this study is that an acute COVID-19 infection, even when considered recovered, may induce changes in the response to non-pharmacological treatment in FM patients, particularly concerning pain.
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