Publications by authors named "C Nardin"
Lysozyme-responsive nanoparticles were fabricated using a hydrophilic protein (gelatin type A) as the core and a hydrophobic polysaccharide (chitosan) as the shell. In this study, curcumin was used as a model molecule for encapsulation and promoted the aggregation of gelatin nanoparticles. Transglutaminase catalyzed both intra-molecular cross-linking within gelatin and inter-molecular cross-linking between gelatin and chitosan.
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- * A study analyzed 12 patients, highlighting key signs like lack of response to antibiotics, symptom improvement after immunosuppressants, and concurrent immune-related issues, suggesting that this sinusitis is noninfectious.
- * There is a need for more studies to determine how common this condition is and its potential impact on patients' outcomes when treated with ICIs.
Vulvar Paget's disease: A population-based cancer registry descriptive study.
J Gynecol Obstet Hum Reprod
December 2024
Article Synopsis
- Vulvar Paget's Disease (VPD) is a rare skin cancer with good outcomes but high recurrence rates, affecting patients' quality of life.
- A study conducted in Franche Comté examined data from 21 patients diagnosed with VPD over 40 years, revealing that many experienced a delayed diagnosis and had a significant likelihood of recurrence, especially after surgical treatment.
- The use of postoperative adjuvant therapies notably improved patients' chances of remaining free from recurrence, highlighting the importance of thorough follow-up care.
Article Synopsis
- The study investigates 16 primary cutaneous carcinomas with mutations in genes that activate the Wnt/β-catenin pathway, noting that these tumors lack matrical differentiation, which is typically associated with such mutations.
- The tumors predominantly affected elderly patients, with a median age of 80, and were mainly located on the head, neck, and upper limbs, leading to metastatic cases in some patients.
- Key findings include poor differentiation in tumor structure, distinct immunohistochemical profiles, and recurrent mutations in APC and CTNNB1, indicating that these tumors represent a unique group apart from other established skin tumor types.