Publications by authors named "C Nardelli"
Research has shown that heightened emotionality often precedes psychotic experiences. Understanding how individuals cope with these emotions is crucial for psychosis. While prior studies on emotion regulation (ER) and psychosis have mainly relied on self-report questionnaires, recent research has increasingly utilised daily life methods.
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- Jumping translocations (JT), linked to disease progression in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), involve the movement of a tri-tetra-somic 1q chromosome to various other chromosomes.
- Research showed that in patients with SRSF2 mutations, JT was associated with changes in DNA methylation during treatment with 5'-azacytidine (AZA), revealing significant shifts in the methylome and impacting various biological pathways.
- The study highlighted that epigenetic modifications, including changes in DNA methylation and specific signaling pathways like PI3K/AKT and MAPK, play a crucial role in the progression of myeloid neoplasms associated with
To date, the increased awareness of the impact of microbes on human health has promoted scientific interest in microbiome studies for diagnostic and therapeutic purposes, revealing correlations between specific taxa and cancer. In particular, numerous species of have been associated with several types of tumors. Previously, we studied the urobiome using Next-Generation Sequencing (NGS), and found an increase in in first morning urine of subjects affected by bladder cancer (BCa).
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- Scientists found a new type of genetic change called t(X;21) in some patients with blood diseases like myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML).
- This change happened along with other mutations in certain genes, but it didn't create new fusion genes as might be expected.
- They discovered that this genetic change is linked to the loss of two important genes (BCOR and RUNX1), which affects how cells behave in these diseases.
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- Research indicates that the urinary microbiome (urobiome) may play a role in bladder cancer (BCa) by causing chronic inflammation that can lead to cancer development, with different bacteria signatures noted among patients based on various factors.
- The study analyzed the urobiome of 48 patients undergoing bladder tumor resection, comparing samples from those with BCa, benign tumors, and healthy individuals to identify potential cancer biomarkers.
- The findings revealed specific bacterial patterns in BCa patients, especially in males over 50, but the study faced limitations due to the low quantity of microbial DNA in some samples, affecting the total number of analyzed BCa patients.