AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection.

The accumulation of damaged mitochondria in the heart is associated with heart failure. Mitophagy is an autophagic degradation system that specifically targets damaged mitochondria. We have reported previously that Bcl2-like protein 13 (Bcl2-L-13) mediates mitophagy and mitochondrial fission in mammalian cells.

Establishing an accountability benchmark for equity, diversity, and inclusion: A 10-year scoping review of Families, Systems, & Health.

Introduction: In 2022, (FSH) issued a statement of purpose to equity, diversity, and inclusion (EDI) and developed a strategic plan for promoting EDI in scientific communication and publishing. The purpose of this review was to evaluate a decade of research published in FSH prior to the journal's initiatives to improve EDI.

Method: We utilized a scoping review to broadly review literature published in FSH that focused on topics of race, ethnicity, racism, and/or BIPOC (Black, Indigenous, and people of color) groups.

Piezoelectric Actuator-Driven Pulsed Water Jet for Neurosurgery: Laboratory Evaluation with the Swine Model and Implications of Mechanical Properties.

Background:  Pulsed water jet is an emerging surgical instrumentation intended to achieve both maximal lesion resection and functional maintenance through preservation of fine vessels and minimal damage to the surrounding tissue. The piezoelectric actuator-driven pulsed water jet (ADPJ) is a new technology that can deliver a precisely controlled uniform and efficient pulsed water jet with minimum water flow. The present study evaluated the ADPJ system in preclinical animal studies in the swine brain, and investigated breaking strength, one of the parameters for mechanical properties, to elucidate the mechanism of tissue selectivity for tissue dissection by the water jet.

Hokuriku-plus familial hypercholesterolaemia registry study: rationale and study design.

Introduction: Familial hypercholesterolaemia (FH) is an autosomal-dominant inherited genetic disease. It carries an extremely high cardiovascular risk associated with significantly elevated low-density lipoprotein (LDL) cholesterol. The diagnostic rate of this disease in some European nations is quite high, due to the presence of multiple prospective registries.