Publications by authors named "C Nagano"
Antihyperglycemic and antioxidant potential of a lectin from in streptozotocin-induced diabetic rats.
Nat Prod Res
January 2025
This study aimed to evaluate the antihyperglycemic and antioxidant activities of the lectin isolated from (BTL). Diabetes was induced in Wistar rats through low-dose streptozotocin injections. Following the confirmation of hyperglycaemia, the animals were treated with 150 mM NaCl, glibenclamide, or BTL at 600 or 900 mg/kg.
View Article and Find Full Text PDFThis study aimed to assess the combined antibacterial effect of lectins and antibiotics on S. aureus ATCC 25923, multidrug-resistant E. coli ATCC 11303 and S.
View Article and Find Full Text PDFArticle Synopsis
- Isotonic fluids, particularly saline and balanced crystalloids, are important for hydration during pediatric kidney biopsies, but there's no clear preference between them.
- A study at Kobe University Hospital evaluated both types of fluids in patients aged 1-19 during kidney biopsies from April 2021 to March 2023, measuring outcomes like hyponatremia and electrolyte balance.
- Results showed no cases of hyponatremia in either group, with saline leading to higher serum chloride and lower bicarbonate levels, but these changes had minimal clinical significance.
Objective: Service evaluation of an urban 'Hospital at Home' service which provides care in patients' homes that would traditionally be delivered in the hospital setting.
Design: Retrospective longitudinal review of routinely collected data recorded contemporaneously for clinical use, analysed to elicit utilisation patterns and service impact.
Setting: A paediatric 'Hospital at Home' service delivered across two large acute hospitals, treating a total of 4427 patients across both primary and secondary care in South London from January 2018 to June 2022.
Structural insights and antimicrobial synergy of a proto-galectin from the marine sponge Aiolochroia crassa.
Comp Biochem Physiol B Biochem Mol Biol
January 2025
Article Synopsis
- A novel lectin called AcrL was isolated from the marine sponge Aiolochroia crassa, which specifically binds to glycans with sialic acid and shows a typical galectin structure with carbohydrate-binding sites.
- AcrL demonstrated strong antibacterial effects by inhibiting biofilm formation in bacteria such as Staphylococcus aureus and Escherichia coli, with varying concentrations required for effectiveness.
- The lectin also enhances the efficacy of antibiotics and damages bacterial membranes, suggesting its potential as a new antibacterial agent in the fight against infections.