Cold Stored Platelets: A Solution for Platelet Aggregation External Quality Assessment/Proficiency Testing.

Background: To achieve accreditation for ISO 15189, laboratories are required to either participate in EQA exercises or intra-laboratory comparisons to meet the standard. Light transmission aggregometry performed by laboratory scientists for the clinical investigation of possible platelet function defects is time dependent. Current EQA available audits the interpretation of platelet aggregation traces.

Provider and Staff Perspectives on Screening and Referral for Social Determinants of Health During Perinatal Care: Implications Using the Consolidated Framework for Implementation Research.

Background: New federal mandates require universal screening and referral for social determinants of health (SDOHs), and evidence exists supporting its integration into primary care practice. However, implementation in maternity care remains understudied and underfunded. To inform maternal health practice, we studied clinical stakeholders' perspectives on SDOH screening and referral knowledge, priority, challenges, and opportunities across four hospital-affiliated obstetrics and gynecology clinics in New Hampshire.

An electronic pre-visit agenda-setting questionnaire in ambulatory palliative care is feasible and acceptable to patients, care partners, and clinicians: A mixed methods evaluation.

Background: To provide patient-centered healthcare for people with serious illness, healthcare teams must elicit needs, goals, preferences, and values from patients and care partners.

Aim: Describe feasibility and acceptability of an electronic pre-visit agenda-setting questionnaire for patients and care partners to identify these topics before ambulatory palliative care visits.

Design: Concurrent mixed-methods formative evaluation of questionnaire feasibility and acceptability.

A review of patient-centred measures in breast cancer care and impact on care efficiency.

ObjectiveBreast cancer is the most common cancer in Australian women, with rising prevalence and costs. Inefficient care leads to poorer outcomes and strains healthcare systems. This review explores the association between breast cancer management strategies and efficiency in delivering care.

Synchronized long-read genome, methylome, epigenome and transcriptome profiling resolve a Mendelian condition.

Resolving the molecular basis of a Mendelian condition remains challenging owing to the diverse mechanisms by which genetic variants cause disease. To address this, we developed a synchronized long-read genome, methylome, epigenome and transcriptome sequencing approach, which enables accurate single-nucleotide, insertion-deletion and structural variant calling and diploid de novo genome assembly. This permits the simultaneous elucidation of haplotype-resolved CpG methylation, chromatin accessibility and full-length transcript information in a single long-read sequencing run.