Publications by authors named "C N Pace"

Background: In COPD patients with severe right-sided emphysema, complete major and incomplete minor fissure, implantation of one-way valves in both the right upper (RUL) and middle lobes (ML) is a possible approach for endoscopic lung volume reduction. The aim of this retrospective analysis was to evaluate the response to therapy and the complication rate at 90 days (90d-FU) after combined RUL-ML valve implantation.

Methods: This retrospective, monocentric study included all patients from the Thoraxklinik Heidelberg who underwent RUL-ML valve treatment between 2012 and 2023 with available follow-up data.

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Previous research indicates that both adults and newborns show enhanced electrophysiological and behavioral responses to schematic face-like configurations (FCs-three dots composing a downward-pointing triangle), as compared to the inverted configurations (ICs). Even fetuses, when exposed to light stimuli projected through the uterine wall, preferentially orient their heads toward FCs rather than ICs. However, when this effect emerges along the third trimester of pregnancy and in relation to the maturation of which brain structures is still unknown.

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Studies suggested that emotion dysregulation and identity processes are involved in social media (SM) misuse, even if their proximal role has not been investigated. Previous studies rarely discriminated between specific activities or between types of SM. We recruited 50 young adults and implemented a momentary ecological assessment measurement.

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Recent unusual mortality events involving skin pathology in bearded (), ringed (), and spotted seals () in Alaska highlight the potential sensitivity of ice-associated species to the complex effects of climate change. The regulation of thyroid hormones, cortisol, and vitamin A have been shown to play essential roles in skin health and seasonal molt in some pinnipeds. Unfortunately, the lack of available reference data for healthy Alaskan ice seals has prevented the adequate evaluation of these factors in cases associated with mortality events.

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Article Synopsis
  • - Alternative splicing includes microexons in neuronal proteins, which are often linked to neurodevelopmental disorders, including autism spectrum disorder (ASD).
  • - A specific 24-nucleotide microexon in the RNA-binding protein CPEB4, previously shown to be less included in individuals with ASD, plays a critical role in regulating gene expression linked to neurodevelopment.
  • - The study finds that this microexon helps maintain the flexible regulation of CPEB4 during neuronal activation by preventing its aggregation, allowing it to switch from repressing to activating translation of genes.
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