Publications by authors named "C N Otis"
Chlamydia muridarum (Cm) has reemerged as a moderately prevalent infectious agent in research mouse colonies. Despite its experimental use, few studies evaluate Cm's effects on immunocompetent mice following its natural route of infection. A Cm field isolate was administered (orogastric gavage) to 8-wk-old female BALB/cJ (C) mice.
View Article and Find Full Text PDFThis study evaluated a therapeutic diet high in eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) of marine source (EPA:DHA ratio 0.69:1), turmeric extract, and hydrolysed collagen in cats ( = 30) with naturally occurring osteoarthritis (OA) over a 13-week (W) period, followed by a 4-W washout, using four previously validated pain/functional outcomes. Compared to the placebo diet, the therapeutic diet significantly improved peak vertical force ( = 0.
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- - The study identifies a new diatom species from the highly alkaline Lake Van in Turkey, characterized through light and scanning electron microscopy on both wild and cultivated samples.
- - Genome analysis revealed that the two monoclonal cultures have very similar DNA sequences with only a few mutations, particularly in the mitochondrial and plastid genomes, indicating some differences in protein coding genes.
- - Phylogenetic analysis placed the new diatom species within the K clade, known for its diversity of species from hypersaline to freshwater environments.
Article Synopsis
- This study investigated the role of micro-RNAs in understanding pain processing in osteoarthritis by using the MI-RAT model, which simulates arthritis in rats.
- Researchers examined various pain responses, structural damage, and neuropeptide levels in both arthritis-affected and healthy rats over a period of 56 days.
- Results indicated significant cartilage damage and persistent pain hypersensitivity in the arthritis group, along with notable changes in neuropeptide expression and microRNA levels that could inform future pain management strategies.
Article Synopsis
- - The study explored feline osteoarthritis (OA) by using electroencephalography (EEG) on conscious cats, employing surface electrodes to avoid altering pain perception usually caused by sedation and intradermal electrodes.
- - Cats were exposed to various sensory stimuli, including mechanical pressure, grapefruit scent, and different wavelengths of light, with results showing significant changes in EEG power, particularly in response to blue light over time.
- - This research marks a breakthrough in understanding and measuring chronic pain in cats, establishing a foundation for future studies on potential sensory interventions to alleviate pain.