Publications by authors named "C N Mingala"

Article Synopsis
  • Avian metaavulavirus 8 (AMAV-8), previously known as avian paramyxovirus 8, has been identified in wild birds globally but had never been reported in China until a recent study.
  • A total of 14,909 samples from wild and domestic birds in China were analyzed, leading to the isolation of the AMAV-8 Y7 strain from a migratory swan goose in 2017.
  • The study revealed that while AMAV-8 does not cause clinical signs in newborn chicks, the virus can replicate in their trachea and shed for up to 8 days, marking important findings about the virus's genetic makeup and behavior in a new region.
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First confirmation of AOAV-16 in domestic and wild birds in China.AOAV-16 are low virulent viruses for chickens.Co-circulation/co-infection of AOAV-16 and H9N2 subtype AIV enhanced pathogenicity.

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Caprine arthritis encephalitis (CAE) is a worldwide economically important disease of small ruminants particularly goats. CAE has been considered to be an emerging/re-emerging disease of goats and a notifiable disease in the Philippines. In this study, a nested-PCR method to detect CAE virus (CAEv) infection was conducted between January 2021 to December 2022.

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Objective: The aerolysin (aerA) is a virulence indicator used to identify the pathogenicity of the strain. Targeting a pathogen's crucial virulence gene for detection is essential, as it determines the potential threat to the host. This study aimed to develop a gold nanoparticle (AuNP) probe for detecting the gene A in among field samples.

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The highly virulent Newcastle disease virus (NDV) isolates typically result in severe systemic pathological changes and high mortality in Newcastle disease (ND) illness, whereas avirulent or low-virulence NDV strains can cause subclinical disease with no morbidity and even asymptomatic infections in birds. However, understanding the host's innate immune responses to infection with either a highly virulent strain or an avirulent strain, and how this response may contribute to severe pathological damages and even mortality upon infection with the highly virulent strain, remain limited. Therefore, the differences in epigenetic and pathogenesis mechanisms between the highly virulent and avirulent strains were explored, by transcriptional profiling of chicken embryonic visceral tissues (CEVT), infected with either the highly virulent NA-1 strain or the avirulent vaccine LaSota strain using RNA-seq.

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