Publications by authors named "C N Melton"
Background And Purpose: Among individuals with diagnosed heart failure (HF), the impact of physical activity on systemic inflammation and risk of hospital admissions remains unclear. This study examines the associations between physical activity and 1) systemic inflammation measured through C-reactive protein (CRP) levels and 2) frequency of hospital admissions in those with HF.
Methods: We utilized data from the National Health and Nutrition Evaluation Survey in this observational cross-sectional study to include 377 community-dwelling adults with HF.
Article Synopsis
- - Outcomes for patients with locally advanced head and neck cancer (HNC) are poor, with a 50% five-year survival rate, so a test to detect molecular residual disease (MRD) in blood is essential to identify recurrence risk within the first two years after treatment.
- - A study involving 325 patients assessed MRD using blood samples collected over time, finding that those with MRD positivity had significantly worse recurrence-free survival rates, particularly in HPV-negative cases.
- - The developed tissue-agnostic test demonstrated high sensitivity (91%) and specificity (88%) for predicting recurrences as much as 14.9 months before they occurred, validating its effectiveness for monitoring HNC patients post-treatment.
Post-traumatic stress disorder (PTSD) is a debilitating disorder characterized by excessive fear, hypervigilance, and avoidance of thoughts, situations or reminders of the trauma. Among these symptoms, relatively little is known about the etiology of pathological avoidance. Here we sought to determine whether acute stress influences avoidant behavior in adult male and female rats.
View Article and Find Full Text PDFBackground: Circulating tumor DNA (ctDNA) positivity at diagnosis, which is associated with worse outcomes in multiple solid tumors including stage I-III non-small cell lung cancer (NSCLC), may have utility to guide (neo)adjuvant therapy.
Methods: In this retrospective study, 260 patients with clinical stage I NSCLC (180 adenocarcinoma, 80 squamous cell carcinoma) were allocated (2:1) to high- and low-risk groups based on relapse versus disease-free status ≤5 years post-surgery. We evaluated the association of preoperative ctDNA detection by a plasma-only targeted methylation-based multi-cancer early detection (MCED) test with NSCLC relapse ≤5 years post-surgery in the overall population, followed by histology-specific subgroup analyses.
Post-traumatic stress disorder (PTSD) is a debilitating disorder characterized by excessive fear, hypervigilance, and avoidance of thoughts, situations or reminders of the trauma. Among these symptoms, relatively little is known about the etiology of pathological avoidance. Here we sought to determine whether acute stress influences avoidant behavior in adult male and female rats.
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