Publications by authors named "C N Hernandez Leon"
Pelvic lymph node dissection (PLND) is the most accurate procedure for lymph node (LN) staging in prostate cancer (PCa) patients. LN sectioning and hematoxylin and eosin (H&E) staining of at least one slice remains the gold standard for LN evaluation, potentially leading to misdetection of small metastatic focus. Entire LN analysis is possible with One-Step Nucleic Acid Amplification (OSNA) by detecting cytokeratin 19 (CK19) mRNA as a surrogate for LN invasion.
View Article and Find Full Text PDFPathogen sequencing is an important tool for disease surveillance and demonstrated its high value during the COVID-19 pandemic. Viral sequencing during the pandemic allowed us to track disease spread, quickly identify new variants, and guide the development of vaccines. Tiled amplicon sequencing, in which a panel of primers is used for multiplex amplification of fragments across an entire genome, was the cornerstone of SARS-CoV-2 sequencing.
View Article and Find Full Text PDFArticle Synopsis
- Axatilimab is a monoclonal antibody that targets CSF-1R, approved for treating chronic graft-versus-host disease (cGVHD) and being researched for other conditions like idiopathic pulmonary fibrosis.
- A study involving 325 participants investigated the drug's pharmacokinetics (PK) and pharmacodynamics (PD), showing that it reduces certain immune cell levels, which affects enzyme levels in the bloodstream.
- The final PK/PD model, based on complex math involving differential equations, identified several factors influencing axatilimab's effectiveness and helped shape dosing strategies for cGVHD patients.
Objective: Neurocognitive symptoms (NCSs) may be early indicators of opioid-related harm. We aimed to evaluate the incidence and potential attribution of opioid-related NCS among patients on long-term opioid therapy (LOT) by using natural language processing to extract data from the electronic health records within the Veterans Health Administration.
Methods: We conducted a retrospective cohort study of patients prescribed LOT in 2018.