Feasibility of controlled nitric oxide generation ascorbate induced chemical reduction of nitrite ions.

Inhalable nitric oxide (iNO) is a lifesaving, FDA-approved drug to improve oxygenation in persistent pulmonary hypertension of the newborn. iNO also has many other applications in lung diseases owing to its vasodilatory and antimicrobial effects. However, its wider therapeutic application is often prohibited by the high cost and logistical barriers of traditional NO/N gas tanks.

Immunoinformatics Design of a Multiepitope Vaccine (MEV) Targeting : A Novel Computational Approach.

Dental caries, a persistent oral health challenge primarily linked to , extends its implications beyond dental decay, affecting over 4 billion individuals globally. Despite its historical association with childhood, dental caries often persists into adulthood with prevalence rates ranging from 60 to 90% in children and 26 to 85% in adults. Currently, there is a dearth of multiepitope vaccines (MEVs) specifically designed to combat .

Antimony centre in three different roles: does donor strength or acceptor ability determine the bonding pattern?

A set of antimony(III) compounds containing a ligand (Ar) with a pendant guanidine function (where Ar = 2-[(MeN)CN]CH) was prepared and characterized. This includes triorgano-Ar3Sb, diorgano-Ar2SbCl and monoorgano-ArSbCl2 compounds and they were characterized by H and C NMR spectroscopy and by single-crystal X-ray diffraction analysis (sc-XRD). The coordination capability of Ar3Sb and Ar2SbCl was examined in the reactions with either -[PdCl(CHCN)] or PtCl and complexes -[(κ-Sb,N-Ar3Sb)MCl] (M = Pd 1, Pt 2) and [(κ-N,Sb,N-Ar2SbCl)MCl] (M = Pd 3, Pt 4) were isolated, while their structures were determined by sc-XRD.

Novel biomarkers reveal mismatch between tissue and serum thyroid hormone status in amiodarone-induced hyperthyroidism.

Context: Serum TSH and thyroid hormone (TH) levels are routine markers of thyroid function. However, their diagnostic performance is limited under special conditions, e.g.