Publications by authors named "C N Boccara"
Live-cell imaging generally requires pretreatment with fluorophores to either monitor cellular functions or the dynamics of intracellular processes and structures. We have recently introduced full-field optical coherence tomography for the label-free live-cell imaging of fungi with potential clinical applications for the diagnosis of invasive fungal mold infections. While both the spatial resolution and technical set up of this technology are more likely designed for the histopathological analysis of tissue biopsies, there is to our knowledge no previous work reporting the use of a light interference-based optical technique for direct mycological examination and monitoring of intracellular processes.
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- - The study aimed to develop indicators for anaesthesia-related severe morbidity to improve the quality and safety of care, addressing limitations in previous research regarding definitions and applicability.
- - A scoping review of 142 studies identified 68 outcomes, which were categorized into 34 indicators related to various health complications, followed by a consensus process with international experts.
- - Ultimately, 26 key indicators with agreed-upon definitions were established, covering conditions like acute heart failure, respiratory issues, sepsis, and medication errors, providing a clearer framework for monitoring severe morbidity in anaesthesia.
As light travels through a disordered medium such as biological tissues, it undergoes multiple scattering events. This phenomenon is detrimental to in-depth optical microscopy, as it causes a drastic degradation of contrast, resolution and brightness of the resulting image beyond a few scattering mean free paths. However, the information about the inner reflectivity of the sample is not lost; only scrambled.
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- The text serves as a correction to a previously published article identified by the DOI 10.1371/journal.pone.0234165.
- The correction addresses specific errors or inaccuracies in the original publication.
- Such amendments aim to ensure the integrity and accuracy of the research findings presented in the article.
Comparative analysis of full-field OCT and optical transmission tomography.
Biomed Opt Express
September 2023
This work compares two tomographic imaging technologies, time-domain full-field optical coherence tomography (FFOCT) working in reflection and optical transmission tomography (OTT), using a new optical setup that combines both. We show that, due to forward-scattering properties, the axial sectioning and contrast in OTT can be optimized by tuning illumination. The influence of sample scattering and thickness are discussed.
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