Publications by authors named "C Musetti"
Importance: Stage at diagnosis is a key prognostic factor for cancer survival.
Objective: To assess the global distribution of breast cancer stage by country, age group, calendar period, and socioeconomic status using population-based data.
Data Sources: A systematic search of MEDLINE and Web of Science databases and registry websites and gray literature was conducted for articles or reports published between January 1, 2000, and June 20, 2022.
Background: Uruguay has the highest cancer incidence and mortality rates in Latin America. The National Cancer Registry of Uruguay, which has been in operation since 1992, provides epidemiological information on incidence and mortality at the country level.
Objective: The objective of this article is to update the incidence and mortality figures by reporting the information for the period 2013-2017.
Colorectal Cancer in Young and Older Adults in Uruguay: Changes in Recent Incidence and Mortality Trends.
Int J Environ Res Public Health
August 2021
Uruguay has the highest colorectal cancer incidence rates in Latin America. Previous studies reported a stable incidence and a slight increase in mortality among males. We aimed to assess colorectal cancer incidence (2002-2017) and mortality trends (1990-2017) by age groups and sex, using data from the National Cancer Registry.
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- A new class of H-PGDS inhibitors, specifically 2-phenylimidazo[1,2-a]pyridine-6-carboxamide, was discovered through a virtual screening process at GlaxoSmithKline.
- Detailed analysis of crystal structures and structure-activity relationships (SAR) resulted in the identification of a powerful, orally active imidazopyridine inhibitor, designated as 20b.
- The text discusses the identification of two types of inhibitors, their synthesis processes, and the challenges encountered during the research.