Publications by authors named "C Muriel"
Objective: To determine the risk factors associated with therapeutic failure of vancomycin in hospitalized adult patients with methicillin-resistant (MRSA) infections.
Design: Case-control study.
Setting: Conducted in a high complexity hospital in Cali, Colombia.
Article Synopsis
- - The RTS,S/AS01 vaccine showed moderate effectiveness against malaria in African infants and children, prompting researchers to investigate how the immune system responds to the vaccination.
- - Using a unique blood transcriptional module framework, the study analyzed immune responses before and after vaccination, revealing significant changes in T-cell activation but fewer indications that these changes directly impacted malaria risk.
- - The findings suggest that certain immune markers present before vaccination are linked to malaria risk, indicating potential roles for specific immune cell types in either promoting or inhibiting vaccine protection.
Flagellum mediated motility is an essential trait for rhizosphere colonization by pseudomonads. Flagella synthesis is a complex and energetically expensive process that is tightly regulated. In Pseudomonas fluorescens, the regulatory cascade starts with the master regulatory protein FleQ that is in turn regulated by environmental signals through the Gac/Rsm and SadB pathways, which converge in the sigma factor AlgU.
View Article and Find Full Text PDFBackground: The BRCA1/2 mutation profile varies in Spain according to the geographical area studied. The mutational profile of BRCA1/2 in families at risk for hereditary breast and ovarian cancer has not so far been reported in Andalusia (southern Spain).
Methods: We analysed BRCA1/2 germline mutations in 562 high-risk cases with breast and/or ovarian cancer from Andalusian families from 2010 to 2015.
The transcriptional regulator AmrZ is a global regulatory protein conserved within the pseudomonads. AmrZ can act both as a positive and a negative regulator of gene expression, controlling many genes implicated in environmental adaption. Regulated traits include motility, iron homeostasis, exopolysaccharides production and the ability to form biofilms.
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