Publications by authors named "C Mornos"
Background: NT-proBNP levels with a wide range at admission play both a diagnostic and a prognostic role in patients with HF. The differences regarding the clinical profiles and demography in decompensated HF patients according to NT-proBNP levels at admission are not clear.
Methods: This study aimed to analyze and compare clinical profiles and demographics in patients hospitalized for decompensated heart failure according to levels of NT-proBNP at admission.
Article Synopsis
- Monoamine oxidases (MAOs) are mitochondrial enzymes that create hydrogen peroxide as a byproduct and have been linked to oxidative stress in heart and metabolic issues.
- This study examined the role of MAOs in oxidative stress within valvular tissues from 30 patients with severe primary mitral regurgitation, focusing on their interaction with angiotensin 2 (ANG2).
- Findings revealed that ANG2 exposure increased MAO expression and reactive oxygen species (ROS) levels, which negatively impacted heart function; however, MAO inhibitors and an angiotensin receptor blocker reduced hydrogen peroxide production.
This study aimed to assess the utility of echocardiography-measured epicardial adipose tissue (EAT) thickness (EATT) as an independent predictor for coronary artery disease (CAD), examining its correlation with oxidative stress levels in epicardial tissue and the complexity of the disease in patients undergoing open-heart surgery. This study included a total of 25 patients referred for cardiac surgery with 14 in the CAD group and 11 in the non-CAD group. Epicardial fat was sampled from patients subjected to open-heart surgery EATT was higher in the CAD group compared to the non-CAD group (8.
View Article and Find Full Text PDFCardiovascular diseases represent the major cause of morbidity mainly due to chronic heart failure. Epicardial (EAT) and perivascular adipose tissues (PVAT) are considered major contributors to the pathogenesis of cardiometabolic pathologies. Monoamine oxidases (MAOs) are mitochondrial enzymes recognized as sources of reactive oxygen species (ROS) in cardiometabolic pathologies.
View Article and Find Full Text PDFOlmesartan medoxomil (OLM) is a selective angiotensin II receptor antagonist used in the treatment of hypertension. Its therapeutic potential is limited by its poor water solubility, leading to poor bioavailability. Encapsulation of the drug substance by two methylated cyclodextrins, namely randomly methylated β-cyclodextrin (RM-β-CD) and heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin (TM-β-CD), was carried out to overcome the limitation related to OLM solubility, which, in turn, is expected to result in an improved biopharmaceutical profile.
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